5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester
Monastrol
CAS: 329689-23-8
Molecular Formula: C14H16N2O3S
5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester - Names and Identifiers
5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester - Physico-chemical Properties
| Molecular Formula | C14H16N2O3S |
| Molar Mass | 292.35 |
| Density | 1.34±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 190-193℃ (ethanol ) |
| Boling Point | 441.3±55.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated) |
| Appearance | White to light yellow solid. |
| Color | White to Off-White |
| pKa | 9.63±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Light Sensitive |
| Use | Monastrol is an inhibitor of mitotic kinin Eg5 with high efficiency and cell permeability, with an IC50 value of 14 μM. |
| In vitro study | Monastrol does not inhibit cell cycle progression through the S and G2 phases of the cell cycle or centrosome replication. The mitotic arrest of monastrol is rapidly reversible. It also inhibits bipolar spindle formation in Xenopus oocyte extracts. Monastrol blocks cells during mitosis, but does not affect microtubules or microtubule polymerization of cells during mitosis in vitro. Exposure of sympathetic neuronal cells to monastrol for several hours increases the number and growth rate of axons. However, the overall length of axons was no different from that of the control group. Sensory neurons also had this effect of a short-term increase in axonal growth rate, however, further prolonged exposure resulted in shorter axons, indicating that sensory neurons were more sensitive to the toxic effects of the drug. However, the overall culture profile of the cells was more robust than in the taxol-treated group, a drug commonly used to treat cancer. In HeLa cells, monastrol activates the spindle checkpoint, leading to mitosis arrest and apoptosis. |
5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester - Risk and Safety
| RTECS | UV6262400 |
5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.421 ml | 17.103 ml | 34.206 ml |
| 5 mM | 0.684 ml | 3.421 ml | 6.841 ml |
| 10 mM | 0.342 ml | 1.71 ml | 3.421 ml |
| 5 mM | 0.068 ml | 0.342 ml | 0.684 ml |
Last Update：2024-01-02 23:10:35
5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester - Reference Information
| biological activity | Monastrol ((±)-Monastrol) is a cell-permeable kinesin-5(KIF11) the small molecule inhibitor, kinesin-5(KIF11), maintains the separation of the semi-spindles. |
| Target | Value |
| KIF11(Eg5) (Cell-based assay) | 14 μM |
Last Update：2024-04-09 21:11:58
Supplier List
Product Name: Monastrol Visit Supplier Webpage Request for quotation
CAS: 329689-23-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 329689-23-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Monastrol Visit Supplier Webpage Request for quotation
CAS: 329689-23-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 329689-23-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History